Transcription co-activators
Team Leader : Patrick SCHULTZ
Department : Integrated structural Biology
Researcher
patrick.schultz@igbmc.fr
Research team(s)
My major scientific interest is to understand the structure-function relationships of multi-protein complexes involved in transcription regulation, DNA repair, and in the modulation of chromatin structure. In my team we use a combination of biochemistry, yeast genetics, molecular biology and structural biology methods in particular high resolution cryo-EM the implementation of which I pioneered in Strasbourg University in the early 90’.
Publications
2025
Article in a journal
Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination
- Mylène Damilot
- Thomas Schoeps
- Laszlo Tora
- Patrick Schultz
- Luc Lebeau
- Gabor Papai
- Adam Ben-Shem
BioRxiv
2024
Article in a journal
Structure of the human TIP60-C histone exchange and acetyltransferase complex
- Changqing Li
- Ekaterina Smirnova
- Charlotte Schnitzler
- Corinne Crucifix
- Alice Brion
- Arnaud Poterszman
- Patrick Schultz
- Gabor Papai
- Adam Ben-Shem
- Jean-Paul Concordet
Nature ; Volume: 635 ; Page: 764-769
Article in a journal
Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
- Ekaterina Smirnova
- Emmanuelle Bignon
- Patrick Schultz
- Gabor Papai
- Adam Ben Shem
eLife ; Volume: 12
2023
Article in a journal
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification
- Alexander Fréchard
- Céline Faux
- Rozalie Hexnerova
- Corinne Crucifix
- Gabor Papai
- Ekaterina Smirnova
- Conor Mckeon
- Florie Lo Ying Ping
- Dominique Helmlinger
- Patrick Schultz
- Adam Ben-Shem
Nature Structural and Molecular Biology ; Volume: 30 ; Page: 1337 - 1345
Article in a journal
Bioactivated and PEG‐Protected Circa 2 nm Gold Nanoparticles for in Cell Labelling and Cryo‐Electron Microscopy
- Nadja Groysbeck
- Victor Hanss
- Mariel Donzeau
- Jean Marc Strub
- Sarah Cianferani
- Danièle Spehner
- Mounib Bahri
- Ovidiu Ersen
- Mikhail Eltsov
- Patrick Schultz
- Guy Zuber
Small Methods
Article in a journal
When transcription initiation meets chromatin
- Patrick Schultz
Nature Structural and Molecular Biology ; Volume: 30 ; Page: 131-133
2021
Article in a journal
Gold labelling of a green fluorescent protein (GFP)-tag inside cells using recombinant nanobodies conjugated to 2.4 nm thiolate-coated gold nanoparticles
- Nadja Groysbeck
- Mariel Donzeau
- Audrey Stoessel
- Anne-Marie Haeberle
- Stéphane Ory
- Danièle Spehner
- Patrick Schultz
- Ovidiu Ersen
- Mounib Bahri
- Dris Ihiawakrim
- Guy Zuber
Nanoscale Advances ; Volume: 3 ; Page: 6940-6948
Article in a journal
Architecture of the multi‐functional SAGA complex and the molecular mechanism of holding TBP, architecture du complexe multifonctionnel SAGA et mécanisme moléculaire de son interaction avec TBP
- Adam Ben-Shem
- Gabor Papai
- Patrick Schultz
FEBS Journal ; Volume: 288 ; Page: 3135-3147
Article in a journal
The NANOTUMOR consortium - Towards the Tumor Cell Atlas
- Florent Colin
- Kristine Schauer
- Ali Hamiche
- Pierre Martineau
- Jean-Paul Borg
- Jan Bednar
- Giulia Bertolin
- Luc Camoin
- Yves Collette
- Stephan Dimitrov
- Isabelle Fournier
- Vincent Hyenne
- Marco A Mendoza-Parra
- Xavier Morelli
- Philippe Rondé
- Izabela Sumara
- Marc Tramier
- Patrick Schultz
- Jacky G Goetz
Biology of the Cell ; Volume: 113 ; Page: 272-280
Chapter of the book
Optimization of Sample Preparation for the Observation of Macromolecular Complexes by Electron (cryo-)Microscopy
- Alexandre Frechard
- Grigory Sharov
- Maximilien Werderer
- Patrick Schultz
Multiprotein Complexes. Methods and Protocols ; Volume: 2247 ; Page: 243-256